Lipids and Lipid Derivatives
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 25 MG
Glycocholic acid is a bile acid with demonstrated anticancer activity. It targets both pump resistance-related and non-pump resistance-related pathways. It increases the cytotoxicity of epirubicin, enhances its intracellular accumulation, and improves its absorption, intensifying epirubicin-induced apoptosis. Combining it with anticancer drugs can help control multidrug resistance by modulating P-gp and MRPs, and by regulating apoptosis-related pathways.
- Increases cytotoxicity of epirubicin
- Enhances intracellular accumulation of epirubicin
- Improves absorption of epirubicin in rat small intestine
- Intensifies epirubicin-induced apoptosis
- Reduces mRNA expression of MDR1, MRP1, and MRP2
- Downregulates MDR1 promoter region
- Suppresses Bcl-2 mRNA expression
- Induces Bax mRNA expression
- Increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9, and -3
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 1 ML
Glycocholic acid is a bile acid with anticancer activity, targeting both pump resistance-related and non-pump resistance-related pathways. It increases the cytotoxicity of epirubicin and significantly increases its intracellular accumulation and absorption.
- Intensifies epirubicin-induced apoptosis.
- Reduces mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2.
- Downregulates the MDR1 promoter region.
- Suppresses the mRNA expression of Bcl-2 and induces the mRNA expression of Bax.
- Increases the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9, and -3.
- Can control multidrug resistance (MDR) by modulating P-gp and MRPs, and regulating apoptosis-related pathways when combined with anticancer drugs.
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 5 G
Glycocholic acid is a bile acid with anticancer activity, targeting pump resistance-related and non-pump resistance-related pathways. It is for research use only and not sold to patients.
- Appearance: Solid
- Color: White to off-white
- Classification: Steroids
- Initial source: Endogenous metabolite, human gut microbiota metabolites
- Increases the cytotoxicity of epirubicin
- Modulates P-gp and MRPs as well as regulating apoptosis-related pathways
Cayman Chemical GlycocholIc AcId-d4 5mg
An internal standard for the quantification of glycocholic acid by GC- or LC-MS
Sigma Aldrich Fine Chemicals Biosciences Estradiol benzoate United States Pharmacopeia (USP) Reference Standard | 50-50-0 | MFCD00003692 | 250MG
Estradiol benzoate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 376.49 | 50-50-0 | MFCD00003692 | 250MG
Medchemexpress LLC U-73343 | 142878-12-4 | 99.43% | 466.66 | 50 MG
U-73343 is an inactive analog of U-73122 that functions as a protonophore and can be used as a negative control. It inhibits acid secretion in a dose-dependent manner, irrespective of the stimulant. U-73122 is known as a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor.
- Potently inhibits acid secretion.
- Does not inhibit K+-pNPPase or H+,K+-ATPase activity.
- Inhibits histamine-, carbachol-, and dbcAMP-stimulated aminopyrine accumulation in gastric glands.
Sigma Aldrich Fine Chemicals Biosciences Estradiol benzoate for system suitability European Pharmacopoeia (EP) Reference Standard | 50-50-0 | MFCD00003692
Estradiol benzoate for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 376.49 | 50-50-0 | MFCD00003692 |
Enzo Life Sciences U-73343 (25 mg). CAS: 142878-12-4
Inactive analog of U-73122 (BML-ST391) which only slightly inhibits phospholipase C. May be used as a negative control. Alternative name: 1-[6-[[(17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-pyrrolidine-2,5-dione. Purity: ≥98% (HPLC). Solubility: Soluble in methylene chloride or chloroform; slightly soluble in DMSO (2mg/ml) or 100% ethanol (1mg/ml); sparingly soluble in aqueous solutions. Long Term Storage: Ambient.
Medchemexpress LLC Bazedoxifene acetate | 198481-33-3 | MFCD09260074 | 99% | C32H38N2O5 | 100 MG
Bazedoxifene acetate, also known as TSE-424 (acetate)-B, is the B-crystal form compound of Bazedoxifene acetate. It functions as an orally active, nonsteroidal selective estrogen receptor modulator (SERM). This product is intended for research use only.
- Orally active, nonsteroidal selective estrogen receptor modulator (SERM)
- IC50s of 23 nM for ERα and 99 nM for ERβ
- Ships at room temperature
- Store at 4°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC Isoflupredone acetate | 338-98-7 | MFCD00468096 | 98.6% | 420.47 g/mol | C23H29FO6 | 5 MG
Isoflupredone acetate (CAS 338-98-7) is a synthetic corticosteroid provided as a research-grade analytical standard used in anti-inflammatory and pharmacological studies. It is intended for laboratory and preclinical research applications and is supplied as a solid powder or as a DMSO solution for assay use.
- High purity for analytical applications.
- Suitable for in vitro and preclinical research.
- Available in small milligram quantities and larger bulk sizes.
- Provided with a batch certificate of analysis.
- Molecular formula C23H29FO6; molecular weight 420.47 g/mol.
Medchemexpress LLC Retinol, acetate, 9-cis- | 29584-22-3 | 85.0% | 328.49 | 1 MG
9-cis-Retinol acetate (also known as 9-cis-Vitamin A acetate or Zuretinol acetate) is a retinal derivative. This white to off-white solid has a molecular weight of 328.49 and a chemical formula of C22H32O2. Intended for research use only, it is suggested to modulate the visual cycle in pharmacotherapy for retinal disease.
- Synonyms: 9-cis-Vitamin A acetate, Zuretinol acetate
- Description: Retinal derivative
- Appearance: White to off-white solid
- Application: Visual cycle modulator in retinal disease pharmacotherapy
- Usage: For research use only
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- Shipping: Room temperature (continental US)