Lipids and Lipid Derivatives
AdipoGen Itaconic acid 4-octyl ester
Chemical. CAS 3133-16-2. Formula C13H22O4. MW 242.3. Derivative of itaconate AG-CN2-0426 https//adipogen.com/ag-cn2-0426-itaconic-acid.html with enhanced cell permeability. Prodrug that is efficiently metabolized to itaconate in cells. Potent anti-inflammatory agent. In vitro it activates the transcription factor nuclear factor erythroid 2-related factor 2 Nrf2 also known as NFE2L2 in LPS-induced mouse and human macrophages. Upregulates Nrf2 levels via a newly identified post-translational modification, dicarboxylation of KEAP1. Alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream gene. Cysteine 151 is uniquely required for inhibiting KEAP1-mediated degradation of Nrf2 and mutating this residue in KEAP1 prevents the stabilization of Nrf2.
Apexbio Technology LLC Medroxyprogesterone acetate 71-58-9 10mM (in 1mL DMSO)
Medroxyprogesterone acetate (MPA) is a synthetic steroidal derivative structurally related to the endogenous hormone progesterone classified as a progestin Acting primarily through binding to progesterone receptors it modulates gene transcription influencing endometrial proliferation and reproductive pathways Additionally MPA exhibits affinity toward glucocorticoid receptors which may contribute to its physiological effects In biomedical research MPA serves as a standard experimental tool to investigate progesterone receptor signaling mechanisms and steroid hormone interactions Furthermore it is widely used in studies focused on reproductive biology contraceptive mechanisms hormone replacement therapy models oncology research involving hormone-responsive tumors and conditions such as endometriosis
Cayman Chemical 7-acetyl PaclItaxel 1mg
An inhibitor of microtubule depolymerization; inhibits calcium-induced microtubule depolymerization at 10 µM; reduces the growth of J774.2 macrophages (IC50 = ~60 nM)
eMolecules 7425-53-8 | Ethyl 4-iodobutyrate | Combi-Blocks | MFCD00045325 | 242.056 | C6H11IO2 | 98.000 | CCOC(=O)CCCI | 5g | 415497677
Ethyl 4-iodobutyrate | Combi-Blocks | 7425-53-8 | MFCD00045325 | 242.056 | C6H11IO2 | 98.000 | CCOC(=O)CCCI | 5g | 415497677
Medchemexpress LLC Aphidicolin | 38966-21-1 | 10 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. This antibiotic is produced by the mold *Cephalosporium aphidicola*. It inhibits cellular deoxyribonucleic acid synthesis, the growth of herpes simplex virus, and exhibits anti-orthopoxvirus activity. Additionally, Aphidicolin can potentiate apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cell lines.
- Inhibits DNA polymerase α and δ.
- Functions as an antibiotic from *Cephalosporium aphidicola*.
- Exhibits antiviral activity against herpes simplex virus and orthopoxvirus.
- Modulates cell cycle, arresting cells at G2 phase.
- Induces apoptosis and inhibits cell proliferation via the p53-GADD45β pathway.
- Aphidicolin glycinate demonstrates anti-tumor activity in murine models.
AdipoGen Resorufin butyrate
Chemical. CAS 15585-42-9. Formula C16H13NO4. MW 283.28. Synthetic. Suitable as fluorogenic substrate for lipases, choline esterases.
Sigma Aldrich Fine Chemicals Biosciences 1alpha,25-Dihydroxyvitamin D3 >=97.0% (HPLC) | 32222-06-3 | MFCD00867079 | 100UG
1alpha,25-Dihydroxyvitamin D3 >=97.0% (HPLC) | Purity: >=97.0% (HPLC) | Mol Wt: 416.64 | 32222-06-3 | MFCD00867079 | 100UG
Medchemexpress LLC Octanoic acid (Standard) | 124-07-2 | 98.95% | 144.21 | 250 MG
Octanoic acid (Standard) is the analytical standard of Octanoic acid, intended for research and analytical applications. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and is used commercially in the production of esters for perfumery and in the manufacture of dyes. This product is for research use only and not sold to patients. The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Suitable for research and analytical applications
- Used in the production of esters for perfumery
- Used in the manufacture of dyes
- Reference standard for qualitative, quantitative, and methodological research experiments
- Applicable in HPLC, GC, and MS
eMolecules 105-45-3 | Methyl acetoacetate | Chem-Impex | MFCD00008784 | 116.116 | C5H8O3 | 99.000 | COC(=O)CC(C)=O | 1kg | 853527456
Methyl acetoacetate | Chem-Impex | 105-45-3 | MFCD00008784 | 116.116 | C5H8O3 | 99.000 | COC(=O)CC(C)=O | 1kg | 853527456
Medchemexpress LLC Geranyl acetate | 105-87-3 | 1 ML
Geranyl acetate is an acyclic monoterpene ester derived from geraniol. Widely used in the cosmetics industry for its pleasant scent, it also acts as an apoptosis activator, showing significant anti-cancer activity against colo-205 cancer cells.
- Induces cell apoptosis
- Exhibits significant anti-cancer activity against colo-205 cancer cells
- Apoptosis associated with upregulation of Bax and downregulation of Bcl-2 expressions
- Acyclic monoterpene ester derived from geraniol
- Widely used in the cosmetics industry for its pleasant scent
- High purity of 99.74%
- Appearance: colorless to light yellow liquid
Medchemexpress LLC D-α-Tocopherol acetate | 58-95-7 | 98.3% | 25 MG
D-α-Tocopherol acetate (D-Vitamin E acetate) is a compound that can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine. It acts as an endogenous metabolite and is supplied as a colorless to light yellow liquid. This compound is intended for research use only.
- Can be hydrolyzed to d-alpha-tocopherol and absorbed in the small intestine.
- Inhibits LPS-induced production of NO, prostaglandin E2, and pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-6) in mouse peritoneal macrophages.
- Exhibits a slight suppression on the activation of NF-κB p50 and p65.